Antiproliferative effect of silver compounds containing benzimidazole ring
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Research Article
VOLUME: 26 ISSUE: 1
P: 1 - 8
April 2025

Antiproliferative effect of silver compounds containing benzimidazole ring

Trakya Univ J Nat Sci 2025;26(1):1-8
1. Erciyes University, Genkok Genome and Stem Cell Center, Kayseri, 38030, TÜRKİYE
2. Suleyman Demirel University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Isparta, 32260, TÜRKİYE
3. Bahçeşehir University, Faculty of Engineering and Natural Sciences, Istanbul, 34353, TÜRKİYE
No information available.
No information available
Received Date: 13.09.2024
Accepted Date: 02.11.2024
Online Date: 20.12.2024
Publish Date: 15.04.2025
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Abstract

With its significant biological activities, the benzimidazole nucleus is a crucial pharmacophore in medicine. Recent studies have focused on the synthesis and biological activity of benzimidazole compounds. Therefore, this study prepared a series of N-heterocyclic silver compounds containing benzimidazole nuclei. These complexes were cultured with lung (A549), colon (CaCo2), breast (MCF7), prostate (PC3) cancer cell lines, and healthy lung (WI38) cell line, and their anticancer effects were investigated through MTT, apoptosis determination, and oxidative stress tests. The results revealed that the presence of drug candidates was more practical than that of commercially used cisplatin.

Keywords:
Apoptosis, cytotoxic activity, Ag-NHC, oxidative stress