Melatonin - leptin interaction and obesity-related genes
PDF
Cite
Share
Request
Review
VOLUME: 26 ISSUE: 1
P: 93 - 102
April 2025

Melatonin - leptin interaction and obesity-related genes

Trakya Univ J Nat Sci 2025;26(1):93-102
1. Department of Biology, Faculty of Science, Canakkale Onsekiz Mart University, 17020 Çanakkale, TÜRKİYE
2. Department of Medical Laboratory Techniques, Vocational School of Health Services, Demiroglu Bilim University, 34750 Istanbul, TÜRKİYE
No information available.
No information available
Received Date: 14.01.2025
Accepted Date: 13.03.2025
Online Date: 21.03.2025
Publish Date: 15.04.2025
PDF
Cite
Share
Request

Abstract

Most living organisms have circadian clocks which maintain rhythm in internal cycles of behavior, physiology, and metabolism, allowing them to anticipate the earth's 24-hour rota-tion. In mammals, circadian integration of metabolic systems optimizes energy gathering and usage across the light and dark cycles. Disruption of circadian rhythms may lead to metabolic dysfunctions such as obesity and obesity-related disorders. The molecular and hormonal mechanism behind obesity is mostly related to mRNA expressions in hypothala-mus, and leptin, and melatonin hormone levels. In obesity and related disorders, the chron-obiotic hormone melatonin regulates physiological functions such as energy metabolism, body fat, and reproduction by cross-interacting with leptin. Leptin signals satiety by inhibit-ing Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP genes in hypothalamus and exerts its effects on food intake, body weight, and the reproductive system. In this review, the mo-lecular and hormonal mechanisms behind obesity were discussed.

Keywords:
Agouti-Related Protein (AgRP), Endocrine, Gene Expression, Neuropeptide Y (NPY), Suprachiasmatic Nuclei (SCN)